<h2>CHAPTER I</h2>
<p class="center"><small>POISONS OF ANTIQUITY</small></p>
<p><span class="smcap">Long</span> before the action of vegetable
and mineral substances
on human beings and animals
was known, it is probable that
poisonous bodies in some form
were used by primitive man.</p>
<p>When injured in battle by
perhaps a flint arrow-head, or
stone axe, he sought for something
to revenge himself on his
enemy. In his search after
curative remedies he also found
noxious ones, which produced
unpleasant effects when applied
to the point of a weapon destined
to enter the internal economy
of an opponent.</p>
<p>He doubtless also became
aware that the spear-points and
arrow-heads on which the blood
of former victims had dried,
caused wounds that rapidly
proved fatal, owing to the action
of what we now call septic
poisons. This probably led to
experiments with the juices of
plants, until something of a
more deadly character was discovered.</p>
<p>This was the very earliest age
of poisoning, when pharmacy
was employed for vicious or revengeful
purposes.</p>
<p>Thus we find that almost every
savage nation and people has
its own peculiar poison. In
Africa the seeds of <em>Strophanthus
hispidus</em>, or kombé, a most
virulent poison, are used for
this purpose; while explorers
tell us that the ancient pigmy
race of Central Africa employ a
species of red ant crushed to a
paste, to tip their arrows and
spears. The South American
Indians poison their arrow-heads
with curare or ourari, produced
from a species of <em>strychnos</em> and
other plants, while the Malays
and hill tribes of India use<span class="pagenum"><SPAN name="Page_12" id="Page_12">12</SPAN></span>
aconite, and other poisonous
juices and extracts. The <em>Antiaris
toxicaria</em> is also used as an
arrow poison by the Malays.</p>
<p>The bushmen of the South
African district "Kalahari," use
the juice of the leaf beetle
"diamphidia" and its larva
for poisoning their arrow-heads.
Lewin, who calls the beetle
<em>Diamphidia simplex</em>, found in
its body, besides inert fatty
acids, a toxalbumin which causes
paralysis, and finally death.
According to Boehm, the poison
from the larva also belongs to
the toxalbumins, and Starke
states, that it causes the dissolution
of the colouring matter of
the blood and produces inflammation.</p>
<p>A halo of mystery, sometimes
intermixed with romance, has
hung about the dread word
<em>poison</em> from very early times.
In the dark days of mythology,
allusions to mysterious poisons
were made in legend and saga.
Thus a country in the Far
North was supposed to be ruled
and dominated by sorcerers and
kindred beings, all of whom
were said to be children of the
Sun. Here dwelt Æëtes, Perses,
Hecate, Medea, and Circe.
Hecate was the daughter of
Perses and married to Æëtes,
and their daughters were Medea
and Circe. Æëtes and Perses
were said to be brothers, and
their country was afterwards
supposed to be Colchis. To
Hecate is ascribed the foundation
of sorcery and the discovery
of poisonous herbs. Her knowledge
of magic and spells was
supposed to be unequalled.
She transmitted her power to
Medea, whose wonderful exploits
have been frequently
described and depicted, and who
by her magic arts subdued the
dragon that guarded the golden
fleece, and assisted Jason to
perform his famous deeds.
Hecate's garden is described by
the poets as being enclosed in
lofty walls with thrice-folding
doors of ebony, which were
guarded by terrible forms, and
only those who bore the leavened
rod of expiation and the concealed
conciliatory offering could
enter. Towering above was the
temple of the dread sorceress,
where the ghastly sacrifices were
offered and all kinds of horrible
spells worked.</p>
<p>Medea was also learned in
sorcery and an accomplished
magician. It is related that,
after her adventures with Jason,
she returned with him to Thessaly.
On their arrival they
found Æson, the father of Jason,
and Pelias, his uncle, who had
usurped the throne, both old
and decrepit. Medea was requested<span class="pagenum"><SPAN name="Page_13" id="Page_13">13</SPAN></span>
to exert her magical
powers to make the old man
young again, an operation she is
said to have speedily performed
by infusing the juice of certain
potent plants into his veins.</p>
<p>Some years after, Medea deserted
Jason and fled to Athens,
and shortly afterwards married
Ægeus, king of that city. Ægeus
had a son by a former wife,
named Theseus, who had been
brought up in exile. At length
he resolved to return and claim
his parentage, but Medea hearing
of this, and for some reason
greatly resenting it, put a poisoned
goblet into the hands of
Ægeus at an entertainment he
gave to Theseus, with the intent
that he should hand it to his son.
At the critical moment, however,
the king cast his eyes on the
sword of Theseus, and at once
recognized it as that which he
had delivered to his son when a
child, and had directed that it
should be brought by him when
a man, as a token of the mystery
of his birth. The goblet was at
once thrown away, the father
embraced his son, and Medea
fled from Athens in a chariot
drawn by dragons through the
air.</p>
<p>Circe's charms were of a more
seductive and romantic character.
She is said to have been
endowed with exquisite beauty,
which she employed to allure
travellers to her territory. On
their landing, she entreated and
enticed them to drink from her
enchanted cup. But no sooner
was the draught swallowed, than
the unfortunate stranger was
turned into a hog, and driven
by the magician to her sty,
where he still retained the consciousness
of what he had been,
and lived to repent his folly.</p>
<p>Gula, the patroness of medicine
and a divinity of the Accadians,
was regarded by that ancient
people as "the mistress
and controller of noxious poisons"
as far back as 5000 years
<small>B.C.</small></p>
<p>According to some authorities,
the Hebrew word <em>Chasaph</em>,
translated in the Old Testament
Scriptures as witch, meant poisoner.
Scott states the witches
of Scripture had probably some
resemblance to those of ancient
Europe, who, although their skill
and power might be safely despised
as long as they confined
themselves to their charms and
spells, were very apt to eke out
their capacity for mischief by
the use of actual poison; so that
the epithet of sorceress and poisoner
were almost synonymous.</p>
<p>The oldest Egyptian king,
Menes, and Attalus Phylometer,
the last king of Pergamus, were
both learned in the knowledge
<span class="pagenum"><SPAN name="Page_14" id="Page_14">14</SPAN></span>
of the properties of plants. The
latter monarch also knew something
of their medicinal uses, and
was acquainted with henbane,
aconite, hemlock, hellebore, etc.
Other Egyptian rulers cultivated
the art of medicine, and there is
little doubt that, probably
through the priests, who were
the chief practitioners of the art
of healing, they gathered a considerable
knowledge of the properties
of many poisonous and
other herbs. Prussic acid was
known to the Egyptians, and
prepared by them in a diluted
form, from the peach and other
plants. It is highly probable,
indeed, that the priests had some
rudimentary knowledge of the
process of distillation, and prepared
this deadly liquid from
peach leaves or stones, by that
method. The "penalty of the
peach" is alluded to in a
papyrus now preserved in the
Louvre, which points to the
liquid being used as a death
draught.</p>
<p>The ancient Greeks, like the
Chinese of to-day, looked upon
suicide, under certain conditions,
as a noble act, for which
poison was the usual medium.
Their "death cup" was mainly
composed of the juice or extract
of a species of hemlock, called
by them cicuta. The Chinese,
from remote times, are supposed
to have used gold as a poison,
especially for suicidal purposes,
and at the present day, when a
high official or other individual
puts an end to his life, it is always
officially announced, "He
has taken gold leaf"; a curious
phrase, which probably has its
origin in antiquity.</p>
<p>Nicander, of Colophon, a
Greek physician, who lived 204-138 <small>B.C.</small>,
in his work on "Poisons
and their Antidotes," the earliest
on the subject known, describes
the effects of snake venom and
the properties of opium, henbane,
colchicum, cantharides,
hemlock, aconite, toxicum (probably
the venom of the toad),
buprestis, the salamander, the
sea-hare, the leech, yew (decomposed),
bull's blood, milk, and
certain fungi, which he terms
"evil fermentations of the
earth"; and as antidotes for
the same he mentions lukewarm
oil, warm water, and mallow or
linseed tea to excite vomiting.
The same writer also made a
rough classification of the poisons
known in his time, twenty-two
in all, and divided them into two
classes—viz., "those which
killed quickly," and "those
which killed slowly."</p>
<p>Of the minerals, arsenic, antimony,
mercury, gold, silver,
copper, and lead were used by
the Greeks; the antidote recommended<span class="pagenum"><SPAN name="Page_15" id="Page_15">15</SPAN></span>
in case of poisoning
being hot oil, and other methods
to induce vomiting and prevent
the poison being absorbed into
the system.</p>
<p>Bull's blood is classed as a
poison by various ancient
writers, and it is recorded that
Æson, Midas King of Phrygia,
Plutarch, and Themistocles,
killed themselves by drinking
bull's blood. It is probable that
some strong poisonous vegetable
substance, such as cicuta, was
mixed with the blood.</p>
<p>Dioscorides throws a further
light on the poisons of antiquity
in his great work on Materia Medica,
which for fifteen centuries
or more remained the chief authority
on that subject. He
mentions cantharides, copper,
mercury, lead, and arsenic.
Among the animal poisons are
included toads, salamanders,
poisonous snakes, a peculiar kind
of honey, and the blood of the
ox, probably after it had turned
putrid. The sea-hare is frequently
alluded to by the ancient
Greeks, and was evidently regarded
by them as capable of
producing a very powerful poison.
Domitian is said to have
administered it to Titus. It is
supposed to have been one of
the genus <em>Aplysia</em>, among the
gasteropods, and is described by
the old writers as a dreadful object,
which was neither to be
touched nor looked upon with
safety.</p>
<p>Among the poisonous plants
enumerated by Dioscorides are
the poppy, black and white hellebore,
henbane, mandragora,
hemlock, elaterin, and the juices
of species of euphorbia, and
apocyneæ. Medea is said to
have been the first to introduce
colchicum. The black and
white hellebore were known to
the Romans, and used by them
as an insecticide, and Pliny
states that the Gauls used a preparation
of veratrum to poison
their arrows. Arsenic was employed
by the Greeks as a caustic,
and for removing hair from
the face; while copper, mercury,
and lead were used in their medical
treatment. The study of
poisons was forbidden for a long
period, and Galen mentions the
fact that only a few philosophers
dared treat the subjects in their
works.</p>
<p>In the East, poisons have
been used from remote times,
not only for the destruction of
human life, but also for destroying
animals—arsenic, aconite,
and opium being employed by
the Asiatics for these purposes.
The Hindoos have many strange
traditions concerning poisons,
some being attributed with the
property of causing a lingering<span class="pagenum"><SPAN name="Page_16" id="Page_16">16</SPAN></span>
death, which can be controlled
by the will of the poisoner. But
this is doubtless more legendary
than correct. One curious and
mysterious substance mentioned
by Blyth, and known in India
as <em>Mucor phycomyces</em>, is stated
to be a species of fungi. When
the spores are administered in
warm water they are said to
attach themselves to the throat
and rapidly develop and grow,
with the result that in a few
weeks, all the symptoms of
consumption develop, and the
victim is rapidly carried off by
that fatal disease.</p>
<p>The early Hebrews were also
acquainted with certain poisons,
the words, "rosch" and
"chema" being used by them
as generic terms. Arsenic was
known to them as "sam,"
aconite as "boschka," and ergot
probably as "son."</p>
<p>The ancients attributed
poisonous properties to certain
bodies simply on account of
their origin being mysterious
and obscure, and many of these
errors and traditions have been
handed down for centuries. As
an instance of this, the belief that
diamond dust possessed deadly
poisonous properties seems to
have existed until recent times.
Many mysterious deaths in the
Middle Ages were attributed to
it. There is little doubt that
death might be caused by the
mere mechanical effect of an
insoluble powder of this kind,
if it were possible to introduce
it into the stomach in sufficient
quantity, but powdered glass
or sand would have the same
effect as diamond dust, viz. in
causing violent irritation of the
stomach. Yet some of these old
traditions have a substratum
of fact.</p>
<p>The poisonous properties of
the toad have long been regarded
as fabulous, but recent
investigation has proved that
the skin of a species of toad
secretes a poison, similar in
action to digitalis.</p>
<p>The venom of the toad has
had the reputation of possessing
poisonous properties from a very
early period, and was probably
one of the earliest forms of
animal poison known.</p>
<p>The old tradition, that King
John was poisoned by a Friar
who dropped a toad into his
wine, was regarded as a ridiculous
fable until some years ago,
when it was discovered that
the skin of the toad secretes a
body, the active principle of
which, "phrynin," is a poison
of considerable power.</p>
<p>One of the most curious uses
to which the toad has been put
is recorded on a medical diploma
now in the Library of Ferrara,<span class="pagenum"><SPAN name="Page_17" id="Page_17">17</SPAN></span>
which was granted to one
Generoso Marini in 1642.
Marini having made application
for a Ferrarese diploma in medicine,
the judges in whom the
power of granting such degrees
was invested, ordered him to
exhibit some efficient proofs of
his capability to practise the
medical art.</p>
<p>Marini at once agreed to
comply with their demand, and
the result is recorded in his
diploma, which was discovered
by Cittadella in the archives
of Ferrara, and is translated as
follows:—</p>
<p>"Having publicly examined
and approved the science and
knowledge of medicine of Signor
Generoso Marini, and his possession
of the wonderful secret
called 'Orvietano,' which he
exhibited on the stage built in
the centre of this our city of
Ferrara, in presence of its entire
population so remarkable
for their civilization and learning,
and in presence of many
foreigners and other classes of
people, we hereby certify that,
also in our presence, as well as
that of the city authorities, he
took several living toads, not
those of his own providing, but
from a great number of toads
which had been caught in fields
in the locality by persons who
were strangers to him, and
which were only handed to him
at the moment of making the
experiment. An officer of the
court then selected from the
number of toads collected, five
of the largest, which the said
Generoso Marini placed on a
bench before him, and in presence
of all assembled spectators,
he, with a large knife, cut all
the said toads in half. Then,
taking a drinking cup, he took
in each hand one half of a dead
toad, and squeezed from it all
the juices and fluids it contained
into the cup, and the same he
did with the remainder. After
mixing the contents together,
he swallowed the whole, and
then placing the cup on the
bench he advanced to the edge
of the stage, where for some
minutes he remained stationary.
Then he became pale as death
and his limbs trembled, and
his body began to swell in a
frightful and terrible manner;
and all the spectators began
to believe that he would never
recover from the poison he had
swallowed, and that his death
was certain. Suddenly, taking
from a jar by his side some of
his celebrated 'Orvietano,' he
placed a portion of it in his
mouth and swallowed it. Instantly,
the effect of this wonderful
medicine was to make
him vomit the poison he had<span class="pagenum"><SPAN name="Page_18" id="Page_18">18</SPAN></span>
taken, and he stood before the
spectators in the full enjoyment
of health.<SPAN name="FNanchor_1_1" id="FNanchor_1_1"></SPAN><SPAN href="#Footnote_1_1" class="fnanchor">[1]</SPAN></p>
<p>"The populace applauded
him highly for the indisputable
proof he had given of his talent,
and he then invited many of the
most learned of those present to
accompany him to his house,
and he there showed them his
dispensary as well as his collection
of antidotes, and among
them a powder made from little
vipers, a powerful remedy for
curing every sort of fever, as he
had proved by different experiments
he had made on
people of quality and virtue,
all of whom he had cured of
the fever from which they were
suffering, etc.</p>
<p>"In consequence of the rare
talent exhibited by Signor
Generoso Marini, and as a proof
of our love and respect for his
wisdom, we have resolved by
the authority placed in our
hands publicly to reward him
with a diploma, so that he may
be universally recognized, applauded,
and respected. In
witness thereof we have set
our hands and the public seal
of the municipality of Ferrara.</p>
<p>"Data in Ferrara con grandissimo
applauso il di 26 Luglio,
1642.</p>
<blockquote>
<p class="hang">"<span class="smcap">Joannes Cajetanus Modoni</span>,
<br/>
"<em>Index sapientum Civitatis
Ferrari</em>.</p>
<p class="hang">"<span class="smcap">Franciscus Altramari</span>,
<br/>
"<em>Cancellarius</em>."</p>
</blockquote>
<p>But although the toad under
certain conditions was credited
with poisonous properties, during
the Middle Ages it was
esteemed a valuable remedy
for the plague, and was employed
for that purpose in
Austria as late as the year 1712.</p>
<p>Cantharides, or Spanish fly,
was very commonly used as a
poison in mediæval times, the
usual method of administering
being to chop it up and mix
it with pepper. It is said to
have been the first poison tried
on the unfortunate Sir Thomas
Overbury, although his murderers
finally finished him off
with corrosive sublimate. Poisoned
rings are said to have
been the invention of the Italians,
who fashioned rings in which
the poison was inserted in a
receptacle where the jewel is
usually set. Attached to the
inner part of the ring was
a sharp point which, when the
hand of the wearer was grasped,
scratched the flesh and injected
the poison. Rings were also<span class="pagenum"><SPAN name="Page_19" id="Page_19">19</SPAN></span>
used for carrying strong poisons
secretly—such as arsenic, or
corrosive sublimate—and in this
manner many were enabled to
commit suicide after being imprisoned.</p>
<p>Hyoscyamus, commonly called
henbane, is a herb which
has been employed from remote
times. Benedictus Crispus,
Archbishop of Milan, in a work
written shortly before <small>A.D.</small> 681,
alludes to it under the name of
hyoscyamus and symphoniaca,
and in the tenth century its
virtues are particularly recorded
by Macer Floridus. In the early
Anglo-Saxon works it is called
henbell and sometimes belene.
In a French herbal of the
fifteenth century it is called
hanibane or hanebane. From
a very early period it has been
employed as a sedative and
anodyne, for producing sleep,
although simple hallucinations
sometimes accompany its use.</p>
<p>An old tradition states, that
once in the refectory of an
ancient monastery the monks
were served with henbane, instead
of some harmless root, in
error by the cook. After partaking
of the dish, they were
seized with the most extraordinary
hallucinations. At midnight
one monk sounded the
bell for matins, while others
walked in the chapel and opened
their books, but could not read.
Others sang roystering drinking
songs and performed mountebank
antics, which convulsed
the others with uncontrollable
laughter, and the pious monastery
for the nonce was turned
into an asylum. Certain stones
which were sold for large sums
of money were supposed to
change colour when brought
near a poisonous substance, and
they were consequently much
sought after by high personages.
The horn of the unicorn was
said to become moist when
placed near poisoned food.
Bickman records his belief that
several slow poisons were known
to the ancients which cannot
now be identified. The Carthaginians
also seem to have been
acquainted with similar poisons,
and, according to tradition, administered
some to Regulus,
the Roman general. But we
cannot endorse Bickman's belief.</p>
<p><span class="err" title="original: And">An</span> incident which happened
to the army led by Mark Antony
against the Parthians, and described
by Plutarch, is said to
have been caused by aconite.
At one time during the expedition,
"the soldiers being very
short of provisions, sought for
roots and pot-herbs ... and
met one that brought on madness
and death. The eater immediately<span class="pagenum"><SPAN name="Page_20" id="Page_20">20</SPAN></span>
lost all memory and
knowledge, busying himself at
the same time in turning and
moving every stone he met
with, as if he were on some important
pursuit. The camp was
full of unhappy men stooping
to the ground, and digging up
and removing stones, till at
last they were carried off by
bilious vomiting.... Whole
numbers perished, and the Parthians
still continued to harass
them. Antony is said to have
frequently exclaimed: 'Oh!
the ten thousand!' alluding to
the army which Xenophon led
in retreat; both a longer way
and through more numerous
conflicts, and yet led in safety."</p>
<p>Nine active or virulent poisons
are mentioned by most ancient
writers on Indian medicine,
many of which are at present
not identified. Most of them
are apparently varieties of
aconite. Besides these, they
employed opium, gunja, datura,
roots of <em>Nerium odorum</em> and
<em>Gloriosa superba</em>, the milky
juices of <em>Calotropis gigantea</em>
and <em>Euphorbia neriifolia</em>, white
arsenic, orpiment, and the poison
extracted from the fangs of
serpents.</p>
<p>Most of the older Sanscrit
MSS. are written on paper prepared
with orpiment to preserve
them from the ravages of insects.
Three varieties of <em>Datura</em> yield
atropine, a powerful poison.
These plants were frequently
employed in India for putting a
sudden end to domestic quarrels,
and to this practice may be
traced the origin of the custom
of "Suttee," or widow burning,
as the Brahmins found
from experience that, by making
a wife's life conterminous with
the husband's the average husband
lived considerably longer.</p>
<p>It is worthy of note that the
diamond was celebrated as a
medicinal agent by the Hindoos,
who prepared it by roasting
seven times and then reducing
it to powder. It was given in
doses of one grain as a powerful
tonic.</p>
<div class="footnote">
<p><SPAN name="Footnote_1_1" id="Footnote_1_1"></SPAN><SPAN href="#FNanchor_1_1"><span class="label">[1]</span></SPAN> The celebrated "Orvietano"
was doubtless some preparation of
antimony.</p>
</div>
<hr class="chap" />
<p><span class="pagenum"><SPAN name="Page_21" id="Page_21">21</SPAN></span></p>
<div style="break-after:column;"></div><br />